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KMID : 1143620190230010069
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Korean Journal of Nuclear Medicine Technology
2019 Volume.23 No. 1 p.69 ~ p.74
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A Study on analysis of contrasts and variation in SUV with the passage of uptake time in 18F-FDOPA Brain PET/CT )
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Seo Kang-Rok
Lee Jeoung-Eun
Ko Hyun-Soo
Ryu Jae-Kwang
Nam Ki-Pyo
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Abstract
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Purpose: 18F-FDOPA using amino acid is particularly attractive for imaging of brain tumors because of the high uptake in tumor tissue and the low uptake in normal brain tissue. But, on the other hand, 18F-FDG is highly uptake in both tumor tissue and normal brain tissue. The purpose of study is to evaluate comparison of contrasts in 18F-FDOPA Brain PET/CT and 18F-FDG Brain PET/CT and to find out optimal scan time by analysis of variation in SUV with the passage of uptake time.
Materials and Methods: A region of interest of approximately 350 mm2 at the center of the tumor and cerebellum in 12 patients (51.4 ±12.8 yrs) who 18F-FDG Brain PET/CT and 18F-FDOPA Brain PET/CT were examined more than once each. The SUVmax was measured, and the SUVmax ratio (T/C ratio) of the tumor cerebellum was calculated. In the analysis of SUV, T/C ratio was calculated for each frame after dividing into 15 frames of 2 minutes each using List mode
data in 25 patients (49. ± 10.3 yrs). SPSS 21 was used to compare T/C ratio of 18F-FDOPA and T/C ratio of 18F-FDG.
Results: The T/C ratio of 18F-FDOPA Brain PET/CT was higher than the T/C ratio of 18F-FDG Brain, and show a significant difference according to a paired t-test(t=-5.214, p=0.000). As a result of analyzing changes in SUVmax and T/C ratio, the peak point of SUVmax was 5.6 ± 2.9 and appeared in the fourth frame (6 to 8 minutes), and the peak of T/C ratio also appeared in the fourth frame (6 to 8 minutes). Taking this into consideration and comparing the existing 10 to 30 minutes image and 6 to 26 minutes image, the SUVmax and T/C ratio increased by 0.2 and 0.1 each, compared to the 10 to 30 minutes image for 6 to 26 minutes image.
Conclusion: From this study, 18F-FDOPA Brain PET/CT is effective when reading the image, because the T/C ratio of
18F-FDOPA Brain PET/CT was higher than T/C ratio of 18F-FDG Brain PET/CT. In addition, in the case of 18F-FDOPA Brain PET/CT, there was no difference between the existing 10 to 30 minutes image and 6 to 26 minutes image. Through continuous research, we can find possibility of shortening examination time in 18F-FDOPA Brain PET/CT. Also, we can help physician to accurate reading using additional scan data.
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KEYWORD
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Brain PET/CT, 18F-FDOPA, SUV, Amino acid brain tumor
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FullTexts / Linksout information
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Listed journal information
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